--- imach/src/imach.c 2022/05/24 08:10:59 1.318 +++ imach/src/imach.c 2022/06/02 04:45:11 1.319 @@ -1,6 +1,10 @@ -/* $Id: imach.c,v 1.318 2022/05/24 08:10:59 brouard Exp $ +/* $Id: imach.c,v 1.319 2022/06/02 04:45:11 brouard Exp $ $State: Exp $ $Log: imach.c,v $ + Revision 1.319 2022/06/02 04:45:11 brouard + * imach.c (Module): Adding the Wald tests from the log to the main + htm for better display of the maximum likelihood estimators. + Revision 1.318 2022/05/24 08:10:59 brouard * imach.c (Module): Some attempts to find a bug of wrong estimates of confidencce intervals with product in the equation modelC @@ -1100,6 +1104,7 @@ Important routines #define POWELLNOF3INFF1TEST /* Skip test */ /* #define POWELLORIGINAL /\* Don't use Directest to decide new direction but original Powell test *\/ */ /* #define MNBRAKORIGINAL /\* Don't use mnbrak fix *\/ */ +/* #define FLATSUP *//* Suppresses directions where likelihood is flat */ #include #include @@ -1190,12 +1195,12 @@ typedef struct { #define ODIRSEPARATOR '\\' #endif -/* $Id: imach.c,v 1.318 2022/05/24 08:10:59 brouard Exp $ */ +/* $Id: imach.c,v 1.319 2022/06/02 04:45:11 brouard Exp $ */ /* $State: Exp $ */ #include "version.h" char version[]=__IMACH_VERSION__; char copyright[]="May 2022,INED-EUROREVES-Institut de longevite-Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research 25293121), Intel Software 2015-2020, Nihon University 2021-202, INED 2000-2022"; -char fullversion[]="$Revision: 1.318 $ $Date: 2022/05/24 08:10:59 $"; +char fullversion[]="$Revision: 1.319 $ $Date: 2022/06/02 04:45:11 $"; char strstart[80]; char optionfilext[10], optionfilefiname[FILENAMELENGTH]; int erreur=0, nberr=0, nbwarn=0; /* Error number, number of errors number of warnings */ @@ -1376,23 +1381,48 @@ double ***cotvar; /* Time varying covari double ***cotqvar; /* Time varying quantitative covariate itqv */ double idx; int **nbcode, *Tvar; /**< model=V2 => Tvar[1]= 2 */ +/* Some documentation */ + /* Design original data + * V1 V2 V3 V4 V5 V6 V7 V8 Weight ddb ddth d1st s1 V9 V10 V11 V12 s2 V9 V10 V11 V12 + * < ncovcol=6 > nqv=2 (V7 V8) dv dv dv qtv dv dv dvv qtv + * ntv=3 nqtv=1 + * cptcovn number of covariates (not including constant and age) = # of + plus 1 = 10+1=11 + * For time varying covariate, quanti or dummies + * cotqvar[wav][iv(1 to nqtv)][i]= [1][12][i]=(V12) quanti + * cotvar[wav][ntv+iv][i]= [3+(1 to nqtv)][i]=(V12) quanti + * cotvar[wav][iv(1 to ntv)][i]= [1][1][i]=(V9) dummies at wav 1 + * cotvar[wav][iv(1 to ntv)][i]= [1][2][i]=(V10) dummies at wav 1 + * covar[k,i], value of kth fixed covariate dummy or quanti : + * covar[1][i]= (V1), covar[4][i]=(V4), covar[8][i]=(V8) + * Model V2 + V1 + V3*age + V3 + V5*V6 + V7*V8 + V8*age + V8 + V9 + V9*age + V10 + * k= 1 2 3 4 5 6 7 8 9 10 11 + */ +/* According to the model, more columns can be added to covar by the product of covariates */ /* ncovcol=1(Males=0 Females=1) nqv=1(raedyrs) ntv=2(withoutiadl=0 withiadl=1, witoutadl=0 withoutadl=1) nqtv=1(bmi) nlstate=3 ndeath=1 # States 1=Coresidence, 2 Living alone, 3 Institution # V1=sex, V2=raedyrs Quant Fixed, State=livarnb4..livarnb11, V3=iadl4..iald11, V4=adlw4..adlw11, V5=r4bmi..r11bmi */ -/* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1 */ -/*k 1 2 3 4 5 6 7 8 9 */ -/*Tvar[k]= 5 4 3 6 5 2 7 1 1 */ -/* Tndvar[k] 1 2 3 4 5 */ -/*TDvar 4 3 6 7 1 */ /* For outputs only; combination of dummies fixed or varying */ -/* Tns[k] 1 2 2 4 5 */ /* Number of single cova */ -/* TvarsD[k] 1 2 3 */ /* Number of single dummy cova */ -/* TvarsDind 2 3 9 */ /* position K of single dummy cova */ -/* TvarsQ[k] 1 2 */ /* Number of single quantitative cova */ -/* TvarsQind 1 6 */ /* position K of single quantitative cova */ -/* Tprod[i]=k 4 7 */ -/* Tage[i]=k 5 8 */ -/* */ +/* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1 */ +/* k 1 2 3 4 5 6 7 8 9 */ +/*Typevar[k]= 0 0 0 2 1 0 2 1 0 *//*0 for simple covariate (dummy, quantitative,*/ + /* fixed or varying), 1 for age product, 2 for*/ + /* product */ +/*Dummy[k]= 1 0 0 1 3 1 1 2 0 *//*Dummy[k] 0=dummy (0 1), 1 quantitative */ + /*(single or product without age), 2 dummy*/ + /* with age product, 3 quant with age product*/ +/*Tvar[k]= 5 4 3 6 5 2 7 1 1 */ +/* nsd 1 2 3 */ /* Counting single dummies covar fixed or tv */ +/*TvarsD[nsd] 4 3 1 */ /* ID of single dummy cova fixed or timevary*/ +/*TvarsDind[k] 2 3 9 */ /* position K of single dummy cova */ +/* nsq 1 2 */ /* Counting single quantit tv */ +/* TvarsQ[k] 5 2 */ /* Number of single quantitative cova */ +/* TvarsQind 1 6 */ /* position K of single quantitative cova */ +/* Tprod[i]=k 1 2 */ /* Position in model of the ith prod without age */ +/* cptcovage 1 2 */ /* Counting cov*age in the model equation */ +/* Tage[cptcovage]=k 5 8 */ /* Position in the model of ith cov*age */ +/* Tvard[1][1]@4={4,3,1,2} V4*V3 V1*V2 */ /* Position in model of the ith prod without age */ +/* TvarF TvarF[1]=Tvar[6]=2, TvarF[2]=Tvar[7]=7, TvarF[3]=Tvar[9]=1 ID of fixed covariates or product V2, V1*V2, V1 */ +/* TvarFind; /**< TvarFind[1]=6, TvarFind[2]=7, TvarFind[3]=9 *//* Inverse V2(6) is first fixed (single or prod) */ /* Type */ /* V 1 2 3 4 5 */ /* F F V V V */ @@ -2363,12 +2393,6 @@ void powell(double p[], double **xi, int double fp,fptt; double *xits; int niterf, itmp; -#ifdef LINMINORIGINAL -#else - - flatdir=ivector(1,n); - for (j=1;j<=n;j++) flatdir[j]=0; -#endif pt=vector(1,n); ptt=vector(1,n); @@ -2492,14 +2516,14 @@ void powell(double p[], double **xi, int /* Convergence test will use last linmin estimation (fret) and compare former iteration (fp) */ /* But p and xit have been updated at the end of linmin, *fret corresponds to new p, xit */ /* New value of last point Pn is not computed, P(n-1) */ - for(j=1;j<=n;j++) { - if(flatdir[j] >0){ - printf(" p(%d)=%lf flat=%d ",j,p[j],flatdir[j]); - fprintf(ficlog," p(%d)=%lf flat=%d ",j,p[j],flatdir[j]); - } - /* printf("\n"); */ - /* fprintf(ficlog,"\n"); */ + for(j=1;j<=n;j++) { + if(flatdir[j] >0){ + printf(" p(%d)=%lf flat=%d ",j,p[j],flatdir[j]); + fprintf(ficlog," p(%d)=%lf flat=%d ",j,p[j],flatdir[j]); } + /* printf("\n"); */ + /* fprintf(ficlog,"\n"); */ + } /* if (2.0*fabs(fp-(*fret)) <= ftol*(fabs(fp)+fabs(*fret))) { /\* Did we reach enough precision? *\/ */ if (2.0*fabs(fp-(*fret)) <= ftol) { /* Did we reach enough precision? */ /* We could compare with a chi^2. chisquare(0.95,ddl=1)=3.84 */ @@ -2537,10 +2561,6 @@ void powell(double p[], double **xi, int } #endif -#ifdef LINMINORIGINAL -#else - free_ivector(flatdir,1,n); -#endif free_vector(xit,1,n); free_vector(xits,1,n); free_vector(ptt,1,n); @@ -2654,6 +2674,13 @@ void powell(double p[], double **xi, int } printf("\n"); fprintf(ficlog,"\n"); +#ifdef FLATSUP + free_vector(xit,1,n); + free_vector(xits,1,n); + free_vector(ptt,1,n); + free_vector(pt,1,n); + return; +#endif } #endif printf("Gaining to use new average direction of P0 P%d instead of biggest increase direction %d :\n",n,ibig); @@ -2738,23 +2765,28 @@ void powell(double p[], double **xi, int newm=savm; /* Covariates have to be included here again */ cov[2]=agefin; - if(nagesqr==1) - cov[3]= agefin*agefin;; + if(nagesqr==1){ + cov[3]= agefin*agefin; + } for (k=1; k<=nsd;k++) { /* For single dummy covariates only */ /* Here comes the value of the covariate 'ij' after renumbering k with single dummy covariates */ cov[2+nagesqr+TvarsDind[k]]=nbcode[TvarsD[k]][codtabm(ij,k)]; + /* cov[++k1]=nbcode[TvarsD[k]][codtabm(ij,k)]; */ /* printf("prevalim Dummy combi=%d k=%d TvarsD[%d]=V%d TvarsDind[%d]=%d nbcode=%d cov=%lf codtabm(%d,Tvar[%d])=%d \n",ij,k, k, TvarsD[k],k,TvarsDind[k],nbcode[TvarsD[k]][codtabm(ij,k)],cov[2+nagesqr+TvarsDind[k]], ij, k, codtabm(ij,k)); */ } for (k=1; k<=nsq;k++) { /* For single varying covariates only */ /* Here comes the value of quantitative after renumbering k with single quantitative covariates */ - cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; + cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; + /* cov[++k1]=Tqresult[nres][k]; */ /* printf("prevalim Quantitative k=%d TvarsQind[%d]=%d, TvarsQ[%d]=V%d,Tqresult[%d][%d]=%f\n",k,k,TvarsQind[k],k,TvarsQ[k],nres,k,Tqresult[nres][k]); */ } for (k=1; k<=cptcovage;k++){ /* For product with age */ - if(Dummy[Tvar[Tage[k]]]){ + if(Dummy[Tage[k]]==2){ /* dummy with age */ cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; - } else{ - cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; + /* cov[++k1]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; */ + } else if(Dummy[Tage[k]]==3){ /* quantitative with age */ + cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; + /* cov[++k1]=Tqresult[nres][k]; */ } /* printf("prevalim Age combi=%d k=%d Tage[%d]=V%d Tqresult[%d][%d]=%f\n",ij,k,k,Tage[k],nres,k,Tqresult[nres][k]); */ } @@ -2763,14 +2795,18 @@ void powell(double p[], double **xi, int if(Dummy[Tvard[k][1]==0]){ if(Dummy[Tvard[k][2]==0]){ cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; + /* cov[++k1]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; */ }else{ cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * Tqresult[nres][k]; + /* cov[++k1]=nbcode[Tvard[k][1]][codtabm(ij,k)] * Tqresult[nres][k]; */ } }else{ if(Dummy[Tvard[k][2]==0]){ cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][2]][codtabm(ij,k)] * Tqinvresult[nres][Tvard[k][1]]; + /* cov[++k1]=nbcode[Tvard[k][2]][codtabm(ij,k)] * Tqinvresult[nres][Tvard[k][1]]; */ }else{ cov[2+nagesqr+Tprod[k]]=Tqinvresult[nres][Tvard[k][1]]* Tqinvresult[nres][Tvard[k][2]]; + /* cov[++k1]=Tqinvresult[nres][Tvard[k][1]]* Tqinvresult[nres][Tvard[k][2]]; */ } } } @@ -2779,7 +2815,7 @@ void powell(double p[], double **xi, int /*printf("ij=%d cov[3]=%lf \n",ij, cov[3]);*/ /* savm=pmij(pmmij,cov,ncovmodel,x,nlstate); */ /* out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm); /\* Bug Valgrind *\/ */ - /* age and covariate values of ij are in 'cov' */ + /* age and covariate values of ij are in 'cov' */ out=matprod2(newm, pmij(pmmij,cov,ncovmodel,x,nlstate),1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, oldm); /* Bug Valgrind */ savm=oldm; @@ -2902,8 +2938,9 @@ void powell(double p[], double **xi, int /* newm points to the allocated table savm passed by the function it can be written, savm could be reallocated */ /* Covariates have to be included here again */ cov[2]=agefin; - if(nagesqr==1) + if(nagesqr==1){ cov[3]= agefin*agefin;; + } for (k=1; k<=nsd;k++) { /* For single dummy covariates only */ /* Here comes the value of the covariate 'ij' after renumbering k with single dummy covariates */ cov[2+nagesqr+TvarsDind[k]]=nbcode[TvarsD[k]][codtabm(ij,k)]; @@ -2924,10 +2961,11 @@ void powell(double p[], double **xi, int /* /\* cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,Tvard[k][1])] * nbcode[Tvard[k][2]][codtabm(ij,Tvard[k][2])]; *\/ */ /* cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; */ for (k=1; k<=cptcovage;k++){ /* For product with age */ - if(Dummy[Tvar[Tage[k]]]){ + /* if(Dummy[Tvar[Tage[k]]]== 2){ /\* dummy with age *\/ ERROR ???*/ + if(Dummy[Tage[k]]== 2){ /* dummy with age */ cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; - } else{ - cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; + } else if(Dummy[Tage[k]]== 3){ /* quantitative with age */ + cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; } /* printf("prevalim Age combi=%d k=%d Tage[%d]=V%d Tqresult[%d][%d]=%f\n",ij,k,k,Tage[k],nres,k,Tqresult[nres][k]); */ } @@ -3353,29 +3391,53 @@ double ***hpxij(double ***po, int nhstep cov[1]=1.; agexact=age+((h-1)*hstepm + (d-1))*stepm/YEARM; /* age just before transition */ cov[2]=agexact; - if(nagesqr==1) + if(nagesqr==1){ cov[3]= agexact*agexact; + } for (k=1; k<=nsd;k++) { /* For single dummy covariates only */ - /* Here comes the value of the covariate 'ij' after renumbering k with single dummy covariates */ +/* Here comes the value of the covariate 'ij' after renumbering k with single dummy covariates */ + /* codtabm(ij,k) (1 & (ij-1) >> (k-1))+1 */ +/* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1 */ +/* k 1 2 3 4 5 6 7 8 9 */ +/*Tvar[k]= 5 4 3 6 5 2 7 1 1 */ +/* nsd 1 2 3 */ /* Counting single dummies covar fixed or tv */ +/*TvarsD[nsd] 4 3 1 */ /* ID of single dummy cova fixed or timevary*/ +/*TvarsDind[k] 2 3 9 */ /* position K of single dummy cova */ cov[2+nagesqr+TvarsDind[k]]=nbcode[TvarsD[k]][codtabm(ij,k)]; /* printf("hpxij Dummy combi=%d k=%d TvarsD[%d]=V%d TvarsDind[%d]=%d nbcode=%d cov=%lf codtabm(%d,Tvar[%d])=%d \n",ij,k, k, TvarsD[k],k,TvarsDind[k],nbcode[TvarsD[k]][codtabm(ij,k)],cov[2+nagesqr+TvarsDind[k]], ij, k, codtabm(ij,k)); */ } for (k=1; k<=nsq;k++) { /* For single varying covariates only */ /* Here comes the value of quantitative after renumbering k with single quantitative covariates */ - cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; + cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; /* printf("hPxij Quantitative k=%d TvarsQind[%d]=%d, TvarsQ[%d]=V%d,Tqresult[%d][%d]=%f\n",k,k,TvarsQind[k],k,TvarsQ[k],nres,k,Tqresult[nres][k]); */ } - for (k=1; k<=cptcovage;k++){ - if(Dummy[Tvar[Tage[k]]]){ + for (k=1; k<=cptcovage;k++){ /* For product with age V1+V1*age +V4 +age*V3 */ + /* 1+2 Tage[1]=2 TVar[2]=1 Dummy[2]=2, Tage[2]=4 TVar[4]=3 Dummy[4]=3 quant*/ + /* */ + if(Dummy[Tage[k]]== 2){ /* dummy with age */ + /* if(Dummy[Tvar[Tage[k]]]== 2){ /\* dummy with age *\/ */ cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; - } else{ - cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; + } else if(Dummy[Tage[k]]== 3){ /* quantitative with age */ + cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; } /* printf("hPxij Age combi=%d k=%d Tage[%d]=V%d Tqresult[%d][%d]=%f\n",ij,k,k,Tage[k],nres,k,Tqresult[nres][k]); */ } - for (k=1; k<=cptcovprod;k++){ /* */ + for (k=1; k<=cptcovprod;k++){ /* For product without age */ /* printf("hPxij Prod ij=%d k=%d Tprod[%d]=%d Tvard[%d][1]=V%d, Tvard[%d][2]=V%d\n",ij,k,k,Tprod[k], k,Tvard[k][1], k,Tvard[k][2]); */ - cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; + /* cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; */ + if(Dummy[Tvard[k][1]==0]){ + if(Dummy[Tvard[k][2]==0]){ + cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * nbcode[Tvard[k][2]][codtabm(ij,k)]; + }else{ + cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)] * Tqresult[nres][k]; + } + }else{ + if(Dummy[Tvard[k][2]==0]){ + cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][2]][codtabm(ij,k)] * Tqinvresult[nres][Tvard[k][1]]; + }else{ + cov[2+nagesqr+Tprod[k]]=Tqinvresult[nres][Tvard[k][1]]* Tqinvresult[nres][Tvard[k][2]]; + } + } } /* for (k=1; k<=cptcovn;k++) */ /* cov[2+nagesqr+k]=nbcode[Tvar[k]][codtabm(ij,k)]; */ @@ -3387,7 +3449,7 @@ double ***hpxij(double ***po, int nhstep /*printf("hxi cptcov=%d cptcode=%d\n",cptcov,cptcode);*/ /*printf("h=%d d=%d age=%f cov=%f\n",h,d,age,cov[2]);*/ - /* right multiplication of oldm by the current matrix */ + /* right multiplication of oldm by the current matrix */ out=matprod2(newm,oldm,1,nlstate+ndeath,1,nlstate+ndeath,1,nlstate+ndeath, pmij(pmmij,cov,ncovmodel,x,nlstate)); /* if((int)age == 70){ */ @@ -3473,10 +3535,11 @@ double ***hbxij(double ***po, int nhstep cov[2+nagesqr+TvarsQind[k]]=Tqresult[nres][k]; /* printf("hPxij Quantitative k=%d TvarsQind[%d]=%d, TvarsQ[%d]=V%d,Tqresult[%d][%d]=%f\n",k,k,TvarsQind[k],k,TvarsQ[k],nres,k,Tqresult[nres][k]); */ } - for (k=1; k<=cptcovage;k++){ /* Should start at cptcovn+1 */ - if(Dummy[Tvar[Tage[k]]]){ + for (k=1; k<=cptcovage;k++){ /* Should start at cptcovn+1 *//* For product with age */ + /* if(Dummy[Tvar[Tage[k]]]== 2){ /\* dummy with age error!!!*\/ */ + if(Dummy[Tage[k]]== 2){ /* dummy with age */ cov[2+nagesqr+Tage[k]]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; - } else{ + } else if(Dummy[Tage[k]]== 3){ /* quantitative with age */ cov[2+nagesqr+Tage[k]]=Tqresult[nres][k]; } /* printf("hBxij Age combi=%d k=%d Tage[%d]=V%d Tqresult[%d][%d]=%f\n",ij,k,k,Tage[k],nres,k,Tqresult[nres][k]); */ @@ -3578,11 +3641,16 @@ double func( double *x) */ ioffset=2+nagesqr ; /* Fixed */ - for (k=1; k<=ncovf;k++){ /* Simple and product fixed covariates without age* products */ - cov[ioffset+TvarFind[k]]=covar[Tvar[TvarFind[k]]][i];/* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1, only V1 is fixed (k=6)*/ + for (k=1; k<=ncovf;k++){ /* For each fixed covariate dummu or quant or prod */ + /* # V1=sex, V2=raedyrs Quant Fixed, State=livarnb4..livarnb11, V3=iadl4..iald11, V4=adlw4..adlw11, V5=r4bmi..r11bmi */ + /* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1 */ + /* TvarF[1]=Tvar[6]=2, TvarF[2]=Tvar[7]=7, TvarF[3]=Tvar[9]=1 ID of fixed covariates or product V2, V1*V2, V1 */ + /* TvarFind; /**< TvarFind[1]=6, TvarFind[2]=7, TvarFind[3]=9 *//* Inverse V2(6) is first fixed (single or prod) */ + cov[ioffset+TvarFind[k]]=covar[Tvar[TvarFind[k]]][i];/* V5+V4+V3+V4*V3+V5*age+V2+V1*V2+V1*age+V1, only V1 is fixed (TvarFind[1]=6)*/ + /* V1*V2 (7) TvarFind[2]=7, TvarFind[3]=9 */ } /* In model V2+V1*V4+age*V3+V3*V2 Tvar[1] is V2, Tvar[2=V1*V4] - is 6, Tvar[3=age*V3] should not be computed because of age Tvar[4=V3*V2] + is 5, Tvar[3=age*V3] should not be computed because of age Tvar[4=V3*V2]=6 has been calculated etc */ /* For an individual i, wav[i] gives the number of effective waves */ /* We compute the contribution to Likelihood of each effective transition @@ -3594,8 +3662,8 @@ double func( double *x) meaning that decodemodel should be used cotvar[mw[mi+1][i]][TTvar[iv]][i] */ for(mi=1; mi<= wav[i]-1; mi++){ - for(k=1; k <= ncovv ; k++){ /* Varying covariates (single and product but no age )*/ - /* cov[ioffset+TvarVind[k]]=cotvar[mw[mi][i]][Tvar[TvarVind[k]]][i]; */ + for(k=1; k <= ncovv ; k++){ /* Varying covariates in the model (single and product but no age )"V5+V4+V3+V4*V3+V5*age+V1*age+V1" +TvarVind 1,2,3,4(V4*V3) Tvar[1]@7{5, 4, 3, 6, 5, 1, 1 ; 6 because the created covar is after V5 and is 6, minus 1+1, 3,2,1,4 positions in cotvar*/ + /* cov[ioffset+TvarVind[k]]=cotvar[mw[mi][i]][Tvar[TvarVind[k]]][i]; but where is the crossproduct? */ cov[ioffset+TvarVind[k]]=cotvar[mw[mi][i]][Tvar[TvarVind[k]]-ncovcol-nqv][i]; } for (ii=1;ii<=nlstate+ndeath;ii++) @@ -3721,8 +3789,13 @@ double func( double *x) } /* end of individual */ } else if(mle==2){ for (i=1,ipmx=0, sw=0.; i<=imx; i++){ - for (k=1; k<=cptcovn;k++) cov[2+nagesqr+k]=covar[Tvar[k]][i]; + ioffset=2+nagesqr ; + for (k=1; k<=ncovf;k++) + cov[ioffset+TvarFind[k]]=covar[Tvar[TvarFind[k]]][i]; for(mi=1; mi<= wav[i]-1; mi++){ + for(k=1; k <= ncovv ; k++){ + cov[ioffset+TvarVind[k]]=cotvar[mw[mi][i]][Tvar[TvarVind[k]]-ncovcol-nqv][i]; + } for (ii=1;ii<=nlstate+ndeath;ii++) for (j=1;j<=nlstate+ndeath;j++){ oldm[ii][j]=(ii==j ? 1.0 : 0.0); @@ -4079,7 +4152,7 @@ void likelione(FILE *ficres,double p[], void mlikeli(FILE *ficres,double p[], int npar, int ncovmodel, int nlstate, double ftol, double (*func)(double [])) { - int i,j, iter=0; + int i,j,k, jk, jkk=0, iter=0; double **xi; double fret; double fretone; /* Only one call to likelihood */ @@ -4113,8 +4186,65 @@ void mlikeli(FILE *ficres,double p[], in if(j!=i)fprintf(ficrespow," p%1d%1d",i,j); fprintf(ficrespow,"\n"); #ifdef POWELL +#ifdef LINMINORIGINAL +#else /* LINMINORIGINAL */ + + flatdir=ivector(1,npar); + for (j=1;j<=npar;j++) flatdir[j]=0; +#endif /*LINMINORIGINAL */ + +#ifdef FLATSUP + powell(p,xi,npar,ftol,&iter,&fret,flatdir,func); + /* reorganizing p by suppressing flat directions */ + for(i=1, jk=1; i <=nlstate; i++){ + for(k=1; k <=(nlstate+ndeath); k++){ + if (k != i) { + printf("%d%d flatdir[%d]=%d",i,k,jk, flatdir[jk]); + if(flatdir[jk]==1){ + printf(" To be skipped %d%d flatdir[%d]=%d ",i,k,jk, flatdir[jk]); + } + for(j=1; j <=ncovmodel; j++){ + printf("%12.7f ",p[jk]); + jk++; + } + printf("\n"); + } + } + } +/* skipping */ + /* for(i=1, jk=1, jkk=1;(flatdir[jk]==0)&& (i <=nlstate); i++){ */ + for(i=1, jk=1, jkk=1;i <=nlstate; i++){ + for(k=1; k <=(nlstate+ndeath); k++){ + if (k != i) { + printf("%d%d flatdir[%d]=%d",i,k,jk, flatdir[jk]); + if(flatdir[jk]==1){ + printf(" To be skipped %d%d flatdir[%d]=%d jk=%d p[%d] ",i,k,jk, flatdir[jk],jk, jk); + for(j=1; j <=ncovmodel; jk++,j++){ + printf(" p[%d]=%12.7f",jk, p[jk]); + /*q[jjk]=p[jk];*/ + } + }else{ + printf(" To be kept %d%d flatdir[%d]=%d jk=%d q[%d]=p[%d] ",i,k,jk, flatdir[jk],jk, jkk, jk); + for(j=1; j <=ncovmodel; jk++,jkk++,j++){ + printf(" p[%d]=%12.7f=q[%d]",jk, p[jk],jkk); + /*q[jjk]=p[jk];*/ + } + } + printf("\n"); + } + fflush(stdout); + } + } + powell(p,xi,npar,ftol,&iter,&fret,flatdir,func); +#else /* FLATSUP */ powell(p,xi,npar,ftol,&iter,&fret,func); -#endif +#endif /* FLATSUP */ + +#ifdef LINMINORIGINAL +#else + free_ivector(flatdir,1,npar); +#endif /* LINMINORIGINAL*/ +#endif /* POWELL */ #ifdef NLOPT #ifdef NEWUOA @@ -4142,6 +4272,14 @@ void mlikeli(FILE *ficres,double p[], in } nlopt_destroy(opt); #endif +#ifdef FLATSUP + /* npared = npar -flatd/ncovmodel; */ + /* xired= matrix(1,npared,1,npared); */ + /* paramred= ma3x(1,nlstate,1,nlstate+ndeath-1,1,ncovmodel); */ + /* powell(pred,xired,npared,ftol,&iter,&fret,flatdir,func); */ + /* free_matrix(xire,1,npared,1,npared); */ +#else /* FLATSUP */ +#endif /* FLATSUP */ free_matrix(xi,1,npar,1,npar); fclose(ficrespow); printf("\n#Number of iterations & function calls = %d & %d, -2 Log likelihood = %.12f\n",iter, countcallfunc,func(p)); @@ -4593,7 +4731,7 @@ void freqsummary(char fileres[], double Title=%s
Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=1+age+%s
\n",\ fileresphtm,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model); } - fprintf(ficresphtm,"Current page is file %s
\n\n

Frequencies and prevalence by age at begin of transition and dummy covariate value at beginning of transition

\n",fileresphtm, fileresphtm); + fprintf(ficresphtm,"Current page is file %s
\n\n

Frequencies (weight=%d) and prevalence by age at begin of transition and dummy covariate value at beginning of transition

\n",fileresphtm, fileresphtm, weightopt); strcpy(fileresphtmfr,subdirfext(optionfilefiname,"PHTMFR_",".htm")); if((ficresphtmfr=fopen(fileresphtmfr,"w"))==NULL) { @@ -4603,11 +4741,11 @@ Title=%s
Datafile=%s Firstpass=%d La exit(70); } else{ fprintf(ficresphtmfr,"\nIMaCh PHTM_Frequency table %s\n %s
%s \ -
\n \ +,
\n \ Title=%s
Datafile=%s Firstpass=%d Lastpass=%d Stepm=%d Weight=%d Model=1+age+%s
\n",\ fileresphtmfr,version,fullversion,title,datafile,firstpass,lastpass,stepm, weightopt, model); } - fprintf(ficresphtmfr,"Current page is file %s
\n\n

Frequencies of all effective transitions of the model, by age at begin of transition, and covariate value at the begin of transition (if the covariate is a varying covariate)

Unknown status is -1
\n",fileresphtmfr, fileresphtmfr); + fprintf(ficresphtmfr,"Current page is file %s
\n\n

(weight=%d) frequencies of all effective transitions of the model, by age at begin of transition, and covariate value at the begin of transition (if the covariate is a varying covariate)

Unknown status is -1
\n",fileresphtmfr, fileresphtmfr,weightopt); y= vector(iagemin-AGEMARGE,iagemax+4+AGEMARGE); x= vector(iagemin-AGEMARGE,iagemax+4+AGEMARGE); @@ -4785,7 +4923,7 @@ Title=%s
Datafile=%s Firstpass=%d La /* } */ } /* end bool */ } /* end iind = 1 to imx */ - /* prop[s][age] is feeded for any initial and valid live state as well as + /* prop[s][age] is fed for any initial and valid live state as well as freq[s1][s2][age] at single age of beginning the transition, for a combination j1 */ @@ -5980,7 +6118,9 @@ void concatwav(int wav[], int **dh, int varhe[ij][ji][(int)age] += doldm[ij][ji]*hf*hf; } } - + if((int)age ==50){ + printf(" age=%d cij=%d nres=%d varhe[%d][%d]=%f ",(int)age, cij, nres, 1,2,varhe[1][2]); + } /* Computing expectancies */ hpxij(p3matm,nhstepm,age,hstepm,x,nlstate,stepm,oldm, savm, cij,nres); for(i=1; i<=nlstate;i++) @@ -6745,7 +6885,8 @@ To be simple, these graphs help to under fprintf(fichtmcov, "\n
********** Variable "); - for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtabm(j1,z1)]); + /* for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtm, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtabm(j1,z1)]); */ + for (z1=1; z1<=cptcoveff; z1++) fprintf(fichtmcov, "V%d=%d ",Tvaraff[z1],nbcode[Tvaraff[z1]][codtabm(j1,z1)]); fprintf(fichtmcov, "**********\n
"); fprintf(ficresprobcor, "\n#********** Variable "); @@ -6774,8 +6915,11 @@ To be simple, these graphs help to under */ /* nbcode[1][1]=0 nbcode[1][2]=1;*/ } - /* for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2]; */ - for (k=1; k<=cptcovage;k++) cov[2+Tage[k]+nagesqr]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; + /* V2+V1+V4+V3*age Tvar[4]=3 ; V1+V2*age Tvar[2]=2; V1+V1*age Tvar[2]=1, Tage[1]=2 */ + /* ) p nbcode[Tvar[Tage[k]]][(1 & (ij-1) >> (k-1))+1] */ + /*for (k=1; k<=cptcovage;k++) cov[2+Tage[k]]=cov[2+Tage[k]]*cov[2]; */ + for (k=1; k<=cptcovage;k++) + cov[2+Tage[k]+nagesqr]=nbcode[Tvar[Tage[k]]][codtabm(ij,k)]*cov[2]; for (k=1; k<=cptcovprod;k++) cov[2+nagesqr+Tprod[k]]=nbcode[Tvard[k][1]][codtabm(ij,k)]*nbcode[Tvard[k][2]][codtabm(ij,k)]; @@ -6986,12 +7130,12 @@ void printinghtml(char fileresu[], char double jprev1, double mprev1,double anprev1, double dateprev1, double dateprojd, double dateback1, \ double jprev2, double mprev2,double anprev2, double dateprev2, double dateprojf, double dateback2){ int jj1, k1, i1, cpt, k4, nres; - + /* In fact some results are already printed in fichtm which is open */ fprintf(fichtm,""); - fprintf(fichtm,"", model); +/* fprintf(fichtm,"", model); */ fprintf(fichtm,"